Home Chemistry Heterocyclic Building Blocks Benzothiophenes 2-(Benzo[B]Thiophen-2-Yl)-4,5-Dihydrooxazole
Substitution Reactions: The oxazole ring in the compound can undergo nucleophilic substitution reactions. For example, you can perform a substitution on the oxazole ring using nucleophiles like amines or alkoxides to replace one of the substituents.
Aromatic Ring Reactions: The benzo[b]thiophene ring is an aromatic ring, so it can undergo typical reactions of aromatic compounds, such as electrophilic aromatic substitution reactions. You can introduce substituents or functional groups onto the benzo[b]thiophene ring using appropriate reagents and conditions.
Heterocycle Transformations: The compound can participate in various reactions involving the modification of heterocyclic rings. For instance, you can perform ring-opening reactions, ring-closure reactions, or ring-expansion reactions on either the oxazole or benzo[b]thiophene ring, depending on the desired product.
Cross-Coupling Reactions: You can use transition metal-catalyzed cross-coupling reactions to introduce various substituents onto the molecule. For example, you can perform Suzuki, Heck, or Stille cross-coupling reactions to create new carbon-carbon bonds.
Oxidation and Reduction Reactions: The compound can undergo oxidation and reduction reactions at specific functional groups if the appropriate reagents and conditions are employed. For instance, you can reduce the oxazole ring to its dihydro form or oxidize it to introduce additional oxygen-containing functional groups.
Nucleophilic Addition Reactions: You can perform nucleophilic additions to the carbonyl group present in the oxazole ring to introduce new substituents or functional groups.
Heterocycle Synthesis: 2-(benzo[b]thiophen-2-yl)-4,5-dihydrooxazole can serve as a starting material for the synthesis of more complex heterocyclic compounds through various cyclization reactions.
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(R)-2-(Benzo[b]thiophen-2-yl)-4-methyl-4,5-dihydrooxazole
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(S)-2-(Benzo[b]thiophen-2-yl)-4-isobutyl-4,5-dihydrooxazole
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(R)-2-(Benzo[b]thiophen-2-yl)-4-isobutyl-4,5-dihydrooxazole
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(S)-2-(Benzo[b]thiophen-2-yl)-4-ethyl-4,5-dihydrooxazole
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(R)-2-(Benzo[b]thiophen-2-yl)-4-ethyl-4,5-dihydrooxazole
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(S)-2-(Benzo[b]thiophen-2-yl)-4-methyl-4,5-dihydrooxazole
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(S)-2-(Benzo[b]thiophen-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole
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(S)-2-(Benzo[b]thiophen-2-yl)-4-isopropyl-4,5-dihydrooxazole
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(R)-2-(Benzo[b]thiophen-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole
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(R)-2-(Benzo[b]thiophen-2-yl)-4-isopropyl-4,5-dihydrooxazole
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